Research

Debilitating diseases and expensive therapies affect governments, communities and individuals substantially, requiring the discovery of new and improved treatments. TAG recipients are mainly focused on diseases such as cancer, with an emphasis on melanoma, and HIV/AIDS all of which are in need of revolutionary approaches. The specific projects funded by the JCTM are listed below.

Principal Investigator

Project Title

Research Area

Pamela Bjorkman of Caltech

Thwarting HIV evasion of antibody avidity with novel antibody architectures

HIV

David Eisenberg of UCLA

An inexpensive, vaginally applied preventative for sexual transmission of HIV

HIV

Scott Fraser of Caltech

Molecular exosome sensor for diagnosis

Cancer

Peter Dervan & Barbara Wold of Caltech. Owen Witte of UCLA.

Translational studies of Py-Im polyamide AR-ARE antagonists

Cancer

Caius Radu, Sanaz Memarzadeh, Oliver Dorigo of UCLA & James Heath of Caltech

Novel immunotherapies against chemotherapy refractory ovarian cancer

Cancer

Sherie Morrison & John Timmerman of UCLA

Antibody-Interferon fusion proteins for cancer treatment

Cancer

Jiaoti Huang & Owen Witte of UCLA

Tissue biomarkers to predict the risk of prostate cancer in patients with increased PSA and negative prostate biopsies

Cancer

John Timmerman & Michael Jung of UCLA

Toll-like receptor 7 agonist-antibody conjugates for the treatment of cancer

Cancer

Ray Deshaies of Caltech & Kathleen Sakamoto of UCLA

Exploiting aneuploidy for cancer therapy

Cancer

Roger Lo & Antoni Ribas of UCLA

Rational targeting of B-RAF inhibitor-resistant melanomas

Melanoma

Thomas Graeber & Roger Lo of UCLA

Phospho-proteomic profiling to define uncharacterized mechanisms of resistance to BRAF inhibitors in patients with metastatic melanoma

Melanoma

Sarkis Mazmanian of Caltech & Martin Hewison of UCLA

Novel therapies for IBD based on optimization of Vitamin D by Gut Bacteria

Inflammatory bowel disease

Henry Lester of Caltech & Marie-Francoise Chesselet of UCLA

Neuroprotection in early-stage Parkinson's disease by nicotine-receptor interaction: Target identification and mechanism of action in mice

Parkinson's Disease

Dianne Newman of Caltech & Sally Ward of CHLA

In pursuit of novel antimicrobial targets: exploring the connection between phenazines, iron speciation and antibiotic resistance in cystic fibrosis airways

Cystic Fibrosis

Dan Kahn of UCLA

Pregnancy enhanced T regulatory cell function to treat autoimmune disease

Autoimmune Disease

Itzhak Fried of UCLA & Christof Koch of Caltech

Using electric fields to control epileptic seizures

Epilepsy

Jane Deng, Genhong Cheng & Huiying Li of UCLA

Alterations in the nasal microbiome following influenza infections

Influenza

Axel Scherer of Caltech & Bahram Jalali of UCLA

Integration of imaging flow cytometry with PCR technology for High Throughput Screening of complex biological fluid

Clinical Diagnostics


Special projects

 

 

James Heath (Caltech)

Defining an effective T-cell response for Cancer Immunotherapies

Cancer

Mark Davis (Caltech)

Circulating microRNAs as diagnostic markers of RNAi in Tumours

Cancer

Caltech & UCLA Collaboration

Melanoma Consortium

Melanoma

Pin Wang (USC)

Dendritic Cell-Targeted Melanoma Immunotherapy

Melanoma

Owen Witte of UCLA

Identifying TCR based immune therapies for prostate and ovarian cancer.

Cancer